Association of spermatogenic failure with decreased CDC25A expression in infertile men
نویسندگان
چکیده
منابع مشابه
Association of spermatogenic failure with decreased CDC25A expression in infertile men.
BACKGROUND DAZ gene family is crucial for human spermatogenesis that requires the precise co-ordination of cell cycle events. CDC25A is recognized as the downstream substrate of DAZ gene family and is thought to function on the M-phase regulation of cell cycles. We investigated the expression profiles of CDC25A in the testes of infertile men and evaluated the relationship between CDC25A levels ...
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The complex process of spermatogenesis requires the expression and precise coordination of a multitude of genes. Abnormal function of such genes is frequently associated with male infertility. Among these candidates is the human BOULE gene that is a possible fundamental mediator of meiotic transition. In this study, we describe for the first time the existence of three BOULE transcript variants...
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BACKGROUND Septins are an evolutionary conserved group of GTP-binding and filament-forming proteins that have diverse cellular roles. An increasing body of data implicates the septin family in the pathogenesis of diverse states including cancers, neurodegeneration, and male infertility. OBJECTIVE The objective of the study was to evaluate the expression pattern of Septin14 in testis tissue of...
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ژورنال
عنوان ژورنال: Human Reproduction
سال: 2006
ISSN: 0268-1161,1460-2350
DOI: 10.1093/humrep/del163